From Colgate.com

“In addition to your regular daily brushing, it’s necessary to use a deep-cleaning solution periodically to soak off food deposits from the denture. These solutions typically come in the form of effervescent tablets, which are specifically formulated to clean dentures.

Avoid using abrasive materials such as brushes with stiff bristles, whitening toothpastes or products containing bleach, according to Mayo Clinic, because these can damage the dentures. Also keep in mind that hot or boiling water can warp your dentures, and soaking items that have metal fittings in any solution containing chlorine can cause the metal to tarnish.

After soaking, check the inside of the denture for any remaining food particles, and brush or scrub using a soft-bristled toothbrush whose shape is conducive to denture care.

Ultimately, ensure that you rinse the dentures exceptionally well afterward; even the gentlest cleansing solution can contain chemicals that are harmful to your mouth’s natural tissues.

Just because you wear dentures doesn’t mean you can’t enjoy the pleasure of freshly-brushed teeth. Complete your denture-cleaning procedure with a thorough brushing of your gums using a soft-bristled toothbrush and everyday, fluoridated toothpaste. If you notice any mouth sores, rinsing with a mouth sore rinse will help to heal them and protect against bacteria in the long term.”